Genetic males with testicular feminization (androgen insensitivity) develop looking and acting female. This condition develops because of a genetic mutation that has which effect? a. It decreases the production of cortisol. b. It prevents the production of testosterone. c. It causes a conversion of testosterone into estradiol within certain cells. d. It prevents testosterone from having its usual effects.

Question

Matias Hays

Biology

4 November, 03:25

Genetic males with testicular feminization (androgen insensitivity) develop looking and acting female. This condition develops because of a genetic mutation that has which effect? a. It decreases the production of cortisol. b. It prevents the production of testosterone. c. It causes a conversion of testosterone into estradiol within certain cells. d. It prevents testosterone from having its usual effects.

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Answers (1)

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Antwan Goodman · Answer 1

The correct option is d. It prevents testosterone from having its usual effects.

Explanation:

Androgen insensitivity syndrome (AIS) is an XY sexual development disorder in which there is a loss of function of the androgen (male hormones) receptor. In this syndrome there is a blockage of the passage of testosterone to dihydrotestosterone (DHT), its most active metabolite, so it's about individuals with development of internal male genitalia (dependent on testosterone) but not external ones (dependent on DHT). The result is that the body does not respond to the masculinizing effect of the hormone testosterone, although the testicle produces it. Within the SIA there are degrees, the so-called complete form (CAIS), where there is no response to testosterone, and the partial form (PAIS), in which there is some response to testosterone but without reaching a completely masculine aspect.