What does it mean when an enzyme is denatured?

a

the active site changes shape

b

more enzymes are formed

c

the enzyme disappears

d

the active site accepts more substrates

The answer should be C) The enzyme disappears.

Pretty sure the answer is D

the active site accepts more substrates

This is why ...

Change the pH and the enzyme stops working. Increasing the temperature to 60°C will cause a permanent change to the shape of the active site. This is why enzymes stop working when they are heated. We say they have become denatured.