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19 April, 10:56

Why might it be more difficult to prepare a vaccine against noroviruses than against rotaviruses?

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  1. 19 April, 11:03
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    Designing efficacious norovirus vaccines remains a major challenge due to several factors:

    (1) the extreme genetic variability within the norovirus family and within genogroups

    (2) the rapid evolution of antigenically dissimilar pandemic GII. 4 norovirus strains

    (3) the lack of lasting immunity upon natural exposure to noroviruses in at least a proportion of the population.
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