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25 August, 00:54

Both epinephrine (a tyrosine derivative) and glucagon (a peptide hormone) increase glucose export from the liver into the bloodstream. Each ligand binds a different receptor, but both lead to an activation of PKA. How does this happen?

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  1. 25 August, 01:12
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    The answer is that the two receptors work as binders, thereby, they activate the same Ga subunit, Gsa, and this indirectly to the activation of PKA.

    Explanation:

    Note that, the action that occurred within the cell depends on heterotrimetric G protein that was activated by the receptor. In specificity, the receptors for glucagon and epinephrine interact with the intracellular Gsa subunit of a heterometric protein. Activation of Gsa leads to the same downstream which signal events, hence the same cellular responses despite the difference between the ligand-receptor interaction.
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