This 1794 uprising was the first real challenge to the new nation's ability to enforce laws and maintain national security.

Answer: Whiskey Rebellion

The Whiskey Rebellion was a tax protest in the United States during the presidency of George Washington. The "whiskey tax" was the first tax that the new federal government imposed on a domestic product. Although the tax applied to all distilled spirits, it became known as the "whiskey tax" due to the popularity of the beverage.