An interaction in which drugs combine in the body to produce extremely uncomfortable reactions is called antagonism. synergism. intolerance. cross-tolerance.

The right option is Intolerance

Drug Intolerance is a situation in which drugs cause adverse effects such as drowsiness or stomach upset and the body is unable to tolerate or bear these effects. An individual with drug intolerance may be able to continue with the drugs if the dose is reduced because drug intolerance sometimes disappears as drug therapy continues.