Neostigmine is an indirect-acting anticholinesterase drug that is used to treat urinary retention by: Multiple Choice1. increasing the release of the antidiuretic hormone. 2. stimulating the hypothalamic thirst centers. 3. inhibiting the release of the antidiuretic hormone. 4. stimulating bladder contractions.

Option D, stimulating bladder contractions.

Explanation:

Neostigmine has a amine structure due to which it can cross the blood brain but once it gets absorbed it is secreted rapidly.

Disabled Urinary retention is a scenario in which the bladder never gets full. Neostigmine leads to accumulation of acetylcholine which triggers concentration based contractions in the urinary bladder. The muscarinic receptor on the urinary bladder contracts the bladder and the contraction gets stronger with passage of time

Hence, option D is correct