M protein is produced by

Pseudomonas aeruginosa

Staphylococcus aureus

Propionibacterium acnes

Streptococcus pyogenes

The correct answer will be option - Streptococcus pyogenes.

Explanation:

M protein is an important virulence factor which is produced and expressed on the surface of Streptococcus pyogenes.

This protein plays important role in the bacterial infection like adherence to epidermal keratinocytes, resistance to phagocytosis, invasion of epithelial cells and microcolony formation.

The M-protein is a α-helical coiled structure protein which consists of the four distinct regions (A-D) in which A-region in the N-terminal is highly variable.

Thus, option - Streptococcus pyogenes is the correct answer.