What effect will the destruction of myelin have on signaling capability of a neuron? Why does this occur?

Destruction of myelin will affect the nerve and there will be the less conduction of electrical impulses from the brain to other parts of the body and the nerve signal sent to the brain are delayed. These damaged nerve areas form sclerosis which disrupts the signalling capacity of the nerve. This may occur due to genetic defects, infectious agents, auto immune reactions and trauma.