These two animations illustrate how p53 binds to DNA to regulate transcription, leading to apoptosis of cells and inhibition of cancer cell growth. Several structural regions of p53 contribute to the anti-tumor function. Why is loop 2 important for p53 function

Question

Brooke Zimmerman

Biology

21 February, 01:08

These two animations illustrate how p53 binds to DNA to regulate transcription, leading to apoptosis of cells and inhibition of cancer cell growth. Several structural regions of p53 contribute to the anti-tumor function. Why is loop 2 important for p53 function

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Answers (1)

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Demetrius Wheeler · Answer 1

The loop 2 is a region involved in binding to DNA, i. e., it is a DNA Binding Domain

Explanation:

The p53 is a well-known protein that acts to activate apoptosis in cancer cells. This protein contains four domains: 1 - an activation domain, 2-a DNA binding domain that recognizes specific DNA sequences, 3 - a domain required to form complexes (responsible for its tetramerization) and 4 - a domain that recognizes mutations in the DNA sequence. Moreover, the p53 protein also comprises folded and unstructured (i. e., intrinsically disordered) regions without a defined structure