The inflammatory response increases the temperature of a skin cell above its normal range. This prevents the cell from quickly performing certain enzyme-catalyzed reactions. Why would this occur

High temperatures denature the enzyme, slowing the reaction.

Explanation:

The activity of an enzyme is altered by temperature. Enzymes are proteins and an increase in temperature leads to the denaturation of their structure. When a protein is denatured, it leads to the loss of its activity, thus losing its secondary and tertiary structure. The main function of enzymes is to increase the rate of a reaction, therefore, if an enzyme is denatured, the rate of reaction will decrease.