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30 January, 21:03

Hemophilia is an X-linked recessive disorder (Xh) that is passed through generations and can be traced by using a pedigree. What is the probability that a female child of Charles and Marie would suffer from hemophilia?

a. 0 percent

b. 25 percent

c. 50 percent

d. 100 percent

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  1. 30 January, 21:10
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    Since hemophilia is an X-linked recessive disorder, the probability depends on the X alleles.

    So, if father has dominant allele (H), the probability that a female child would suffer from hemophilia (genotype: hh) is 0%, no matter of mother's genotype:

    Father Mother

    Parents: H x Hh

    Daughter: HH or Hh

    Father Mother

    Parents: H x HH

    Daughter: HH

    Father Mother

    Parents: H x hh

    Daughter: Hh or Hh

    But, if the father has recessive allele, the probability that a female child would suffer from hemophilia (genotype: hh) will depend on mother's genotype.

    If mother is dominant homozygous, there will be 0% of possibility:

    Father Mother

    Parents: h x HH

    Daughter: Hh

    If mother is recessive homozygous, the possibility is 100%:

    Father Mother

    Parents: h x hh

    Daughter: hh

    If mother is heterozygous, the possibility is 50%:

    Father Mother

    Parents: h x Hh

    Daughter: Hh or hh
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