Sickle cell anemia is a life-threatening disorder caused by a genetic mutation that alters a single amino acid in the beta-globin protein. Due to this mutation, a hydrophilic glutamic acid residue normally present on the outer surface of the protein is replaced by valine, a hydrophobic amino acid. This mutation does not substantially alter the tertiary structure of hemoglobin. Which of the following is a consequence of this mutation?

1. The mutation causes hemoglobin molecules to stick together due to the hydrophobic effect.

2. The mutation prevents the post-translational modification and activation of hemoglobin.

3. The mutation alters the folding of the hydrophobic core of hemoglobin.

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21 September, 15:52

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Vincent Wells · Answer 1

2 is the answer I THINK look at other ones first