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14 July, 17:56

Answer the following considering Chargaff's rules. Suppose a 100-base-pair, double-stranded DNA molecule consists of 50% of guanine bases. How many total hydrogen bonds are holding the two strands together?

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  1. 14 July, 18:05
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    250 H bonds

    Explanation:

    The Chargaff rule states that a DNA molecule has the following features-

    1. Purine binds pyrimidines through hydrogen bond

    2. The sum of purine and pyrimidine is equal to 1.

    3. Adenine binds thymine always (involve two H bonds)

    4. Guanine binds cytosine (involves three H bonds)

    In the given question,

    guanine bases - 50, therefore, cytosine bases will be 50

    H bond will be 50 x 3 = 150 bonds

    Similarly,

    Adenine bases will be 50 equal thymine which will also be 50

    double H bond will be - 50 x 2 = 100

    Total H bond will be - 250 H bonds.

    Thus, 250 H bonds are the correct answer.
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