In the Meselson-Stahl experiment, which mode of replication was eliminated based on data derived after one generation of replication

Conservative mode of replication

Explanation:

Meselson and Stahl performed the experiment to test how the DNA molecule replicates in the organisms.

He performed the experiment on E. coli by culturing them in N¹⁵ isotope and then transferring them to N¹⁴ isotope.

When he analysed the DNA sample through density centrifugation he found that in Generation One or one round of replication the intermediate band between the N¹⁴ isotope (lighter) and N¹⁵ isotope (heavier) isotopes.

This result showed that now the DNA contains both forms of isotope that is it is in favour of the semi-conservative and dispersive mode of replication but not conservative mode pf replication.

Thus, Conservative mode of replication is the correct answer.