In the heterozygous state (w + / w), a variegated eye is produced, with white and red patches. How might one explain position-effect variegation in terms of histone acetylation and/or deacetylation?

Question

Niko Sims

Biology

3 December, 13:39

In the heterozygous state (w + / w), a variegated eye is produced, with white and red patches. How might one explain position-effect variegation in terms of histone acetylation and/or deacetylation?

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Answers (1)

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Koty · Answer 1

2. The white patches are caused by the deacetylation of the histones associated with the DNA of the w + allele.

3. The red patches are caused by the acetylation of the histones associated with the DNA of the w + allele.

Explanation:

The complete question is as follows:

How might one explain position-effect variegation in terms ofhistone acetylation and/or deacetylation? Select all thatapply.

1. The white patches are caused by the acetylation of the histonesassociated with the DNA of the w + allele.

2. The white patches are caused by the deacetylation of thehistones associated with the DNA of the w + allele.

3. The red patches are caused by the acetylation of the histonesassociated with the DNA of the w + allele.

4. The red patches are caused by the deacetylation of the histonesassociated with the DNA of the w + allele.

In the W+/W State variegated eye is produced, however in reality the W + allele causes a red eye colour whereas the W allele causes a white eye.

The reason for production of variegated eyes is chromosomal rearrangement.

Due to the chromosomal rearrangement the W + gene's position gets changed and it moves from a region of euchromatin to heterochromatin and this position affect leads to red and white patches in the eye.

The heterochromatin is silent region of the genome which does not encode for any product and this is caused by histone deacetylation whereas the histone acetylation makes the chromosomes more accessible and contributes the euchromatin region.