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19 March, 03:28

Sometimes errors called mutations occur during DNA replication. What are some of the possible consequences of mutations?

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  1. 19 March, 03:46
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    By the same token, any random change in a gene's DNA is likely to result in a protein that does not function normally or may not function at all. Such mutations are likely to be harmful. Harmful mutations may cause genetic disorders or cancer. A genetic disorder is a disease caused by a mutation in one or a few genes
  2. 19 March, 03:54
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    Answer: Mutation can lead to cancer and other genetic diseases.

    Explanation: Mutation is a permanent change in a DNA (deoxyribonucleic acid) nucleotide sequence. DNA can be mutated by substitution/replacement of one or more base pairs, insertion/addition or deletion of one or more base pairs. When the mutation is not repaired by the DNA repair system, it can be transmitted to a younger generation. Mutation caused by base substitution can be silent if it affects nonessential DNA, while other mutations can be deleterious. Mutation can be missense if the base substitution produces a codon that codes a different amino acid and leads to the synthesis of a different polypeptide chain.

    A base substitution can be nonsense if it results in a termination codon that stops the process of translation. Sickle cell disease results from a single base substitution whereby valine replaces glutamate at the sixth position of the beta globin chain.

    Deletion of a base pair can result in alteration of the translational frame thereby producing a nonfunctional protein.
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