A woman who has sickle cell anemia passes this disease on to her offspring. This means that the mutation for sickle cell anemia must occur in the woman's what?

The mutation will occur on the X chromosome. Males are more susceptible to sickle cell amenia because they only carry one X chromosome instead of two when compared to a set of female chromosomes. If a female only has the mutation on one chromosome the disease will not appear. However, when a male recieves the mutation on the X chromosome, the disease would appear, because they only have one X chromosome.