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9 November, 14:11

A gene exists in two alleles, which we will call B and b. The gene is 1123 bp in length, and the B and b alleles exhibit single base pair differences at six different sites. If gene conversion changed the b allele into the B allele, which mechanism would you favor to explain the conversion

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  1. 9 November, 14:37
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    The below options will complete the question

    Select one:

    a. Gap repair synthesis

    b. Mismatch repair

    c. Direct repair

    d. Nucleotide excision repair

    Our answer is surely A.

    a. Gap repair synthesis

    Explanation:

    Alleles of gene B differ by 6 bps and are seeming close to each other among the 1123 bp within the particular gene, favouring the gap repair synthesis.

    In the gap repair synthesis, a double stranded break is formed at a homologous chromosome with a small part of the gene or the 6 bps of the recessive allele

    being digested away.

    Strand invasion and a D-loop formation is followed by the new region being occupied by the dominant B allele to yielding dominant B allele in both chromosomes.

    The gap repair synthesis allows the 6bps to be converted to the dominant B from the recessive b when in proximity/being close together.
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