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9 February, 00:37

Why does sickle-cell hemoglobin (HbS) migrate slower than normal hemoglobin (HbA) during gel electrophoresis?

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  1. 9 February, 01:07
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    The cause a translocation of the amino acid in position of a normal beta globin, transforming glutamic acid into valine. Then the HBs has less charge due to loss of the glutamic acid. Sickle-cell anemia is a hereditary disease make by hemoglobin S in its homozygous form.
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