What happens if an enzyme is denatured? How does that impact the reaction rate?

An enzyme is a biological protein molecule made up of thousands of amino acids ... Enzymes work consistently until they are dissolved, or become denatured. When enzymes denature, they are no longer active and cannot function. extreme high temperatures can cause an enzyme to lose its shape (denature) and stop working ... Extreme pH values can cause enzymes to denature. Enzyme concentration: Increasing enzyme concentration will speed up the reaction, as long as there is substrate available to bind to.