A nurse is teaching a group of clients with peripheral vascular disease about a smoking cessation program. which physiologic effect of nicotine should the nurse explain to the group?

She should mention the effect of nicotine on vasoconstriction. When nicotine is ingested, it can cause blood vessels in the peripheries to narrow and leads to an increase in blood pressure. This can lead to any number of deleterious outcomes, such as hypertension and heart disease.