Partially blocks H + pyruvate symprtyer interfering with the transport of pyruvate into the mitochondria is it potentially effective in promoting weight lose or gain weight

The interference with the transport of pyruvate into mitocondria results in weight gain.

Explanation:

Pyruvate is the end product of glycolysis. After being formed the pyruvate is transported into mitochondria to carry out the second stage of aerobic respiration that is TCA cycle.

Now if the pyruvate is not transported into mitochondria then the pyruvate will accumulate in the cytosol. The accumulation of pyruvate prevent further breakdown of glucose.

As a result the uncatabolized glucose is the converted into glycogen and the glycogen will accumulate in the liver and muscle leading to weight gain.