Voltage across the cell membrane is determined by the concentration of which 2 types of charged particles?

The answer is; Sodium (Na+) and Potassium (K+) Ions

These cations are pumped out of the cell by Na+-K + transmembrane protein pumps leaving the inside of the cell electronegative in relation to the extracellular matrix. This membrane potential is significant especially for neurons. Depolarization of the membrane enables transmissions of an impulse along the neurons.