In a human germ cell, a replication slippage event occurs during the round of DNA replication just before meiosis. The slippage event occurred within the DNA sequence that encodes for the first exon of the KRT1 gene. The KRT1 gene encodes for the protein keratin which is found highly expressed in skin cells. The slippage event described has the potential to result in what type of mutation?

A. a somatic missense mutation

B. a somatic frameshift mutation

C. a somatic silent mutation

D. a germline missense mutation

E. a germline frameshift mutation

F. a germline silent mutation

Option - (E) : In a human germ cell, a replication slippage event occurs during the round of DNA replication just before meiosis. The slippage event occurred within the DNA sequence that encodes for the first exon of the KRT1 gene. The KRT1 gene encodes for the protein keratin which is found highly expressed in skin cells. The slippage event described has the potential to result in a germ-line frame-shift mutation.

Explanation:

The change or alternation inside the given sequence present inside the germ-line gives rise to the frame-shift mutation which happens to be result of the meiosis process.

The correct option from the given options is E which is germline frameshift mutation.

Explanation:

As per the question meiosis occurs in germ cell such that this mutation result in KRT1 gene mutation while slippage mutation cause change in frame by slipping some bases during replication. So this is frameshift mutation. This mutation is such that the gene is altered so a frameshift mutation.