Which statement best explains he relationship between hbs allele frequency and malaria

endemicity in africa

HbS allele is the sickle cell hemoglobin allele, which generates natural immunity to malaria. Therefore, natural choice will facilitate the populace with HbS allele within a Malaria holoendemic region.

It is verified that in a holoendemic area (African malaria infested area), the HbS allele frequency remains between 0.52 and 4.04.