What must investigators do prior to making any significant changes in their use of animals?

Explained below:

Explanation:

Investigators are responsible for the security of the research animals in their attention from the most initial stages of the plan until a study is finished.

As before using animals, investigators must have IACUC approval, before implementing significant changes in their use of animals, investigators also need to get IACUC approval necessarily. Pontificating changes in the use of animals that may be a dormant change in scope, which includes changes in the production section.