Is the structure of DNA important for the process of DNA replication?

Basically structure of DNA is very important in the process of replication.

DNA molecules have antiparallel structure i. e. the two strands of the halix run in opposite directions of one another. Each strand has 5 prime end and 3 prime end. Solving the structure of DNA unlocked the door to understanding many of the function of DNA, such as how it copied and how the information it carries can be used to produce protein.