Many antibiotics inhibit bacterial protein synthesis. For example, tetracycline blocks the A site on the bacterial ribosome, and chloramphenicol blocks peptidyl transfer. What specific effect would you expect each of these antibiotics to have on protein synthesis? Chloramphenicol would directly affect

Question

Autumn Brock

Biology

1 June, 20:25

Many antibiotics inhibit bacterial protein synthesis. For example, tetracycline blocks the A site on the bacterial ribosome, and chloramphenicol blocks peptidyl transfer. What specific effect would you expect each of these antibiotics to have on protein synthesis? Chloramphenicol would directly affect

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Timothy · Answer 1

Tetracycline affects the binding of tRNA to the ribosome. Chloraamphenicol affect: growth of the protein chain.

Explanation:

1. Antibiotics block protein synthesis mostly in prokaryotes only as prokaryotes contain 70s ribosome.

2. Antibiotics are of various types, which have different targets in protein synthesis, some works on small sub-unit of ribosome and some on large sub-unit.

⇒Tetracycline would directly affect binding of tRNA to the A site on ribosome. tRNA brings amino acid to the ribosome which pairs with codon on mRNA.

⇒ Chloraamphenicol would directly affect growth of the protein chain because it block peptidyl transfer so the elongation of protein terminates.