An enhancer may increase the frequency of transcription initiation for its associated gene when ... (indicate true or false for each statement and explain your answer ...) A ... it is located 1000 nucleotides upstream of the gene's core promoter. B ... it is located 1000 nucleotides downstream of the gene's core promoter. C ... it is in the gene's coding region.

it is located 1000 nucleotides upstream of the gene's core promoter - true

it is located 1000 nucleotides downstream of the gene's core promoter - true

it is in the gene's coding region - False

Explanation:

These enhancers are located 50 or more kilobases from the promoter they controlled upstream from a promoter, downstream from a promoter within an intron, or even downstream from the final exon of a gene which can be thousands of bp away from the gene's core promoter and can also occur thousands of nucleotides away from the gene's core promoter needing the activity of a DNA - bending protein that binds to the enhancer changing the shape of the DNA and allow interactions between the activators and transcription factors.