You are a brilliant student who has discovered a new genetic disease identified by the absence of a key enzyme involved in the Krebs cycle. You work diligently to discover that the missing enzyme is produced in the cytoplasm as a zymogen, but does not get to its correct location in the mitochondria. What is the problem

Question

Aliana Nguyen

Biology

10 April, 17:35

You are a brilliant student who has discovered a new genetic disease identified by the absence of a key enzyme involved in the Krebs cycle. You work diligently to discover that the missing enzyme is produced in the cytoplasm as a zymogen, but does not get to its correct location in the mitochondria. What is the problem

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Answers (1)

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Gillespie · Answer 1

The given question in incomplete, the complete question is:

You are a brilliant student who has discovered a new genetic disease identified by the absence of a key enzyme involved in the Krebs cycle. You work diligently to discover that the missing enzyme is produced in the cytoplasm as a zymogen, but does not get to its correct location in the mitochondria. What is the problem?

Group of answer choices

the signal peptide on the N-terminus of the protein may be incorrect or missing

the functioning of the Krebs in the matrix

enzymes allow some reactions to occur but not others

dephosphorylation did not occur

Answer:

The correct answer is that on the N-terminus of the protein the signal peptide may be missing or incorrect.

Explanation:

The metabolic reactions of several enzymes that take place within the mitochondria are generated with the assistance of genes produced within the nucleus. The translation of these gene products takes place within the cytoplasm and is targeted towards the mitochondria.

In case, if a flaw is witnessed at the time of targeting towards the mitochondria, the protein would stay within the cytoplasm and will not move forward. Therefore, error in the signal peptide would be the correct option.