A history of repeated chronic infections due to an acquired B-cell deficiency and decreased antibody production and/or function is usually indicative of

Common variable immunodeficiency disease (CVID).

Explanation:

CVID (Common variable immunodeficiency disease) is a medical disease in which the body suffers from the antibody deficiency. The body get easily attacked by the pathogens in this disease.

The chronic infections get repeated in this disease. The B cell deficiency causes the decreased or non functional antibodies in CVID. Genetic mutations are responsible for this disease.

Thus, the answer is Common variable immunodeficiency disease (CVID).