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3 July, 03:36

Suppose that a mutation of the above enzyme decreases the catalytic rate by 4 orders of magnitude. the decreased rate indicates that the mutation has caused δg° to increase. by how many kj/mol has the activation energy increased in the mutant enzyme compared to the wild-type (unmutated) enzyme?

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  1. 3 July, 03:40
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    We know that reate constant (-Ea/RT)

    K = Ae^ (-Ea/RT)

    A = frequency factor

    Ea = activation energy

    R = constant

    T = temperature

    Let us take two rate constants

    K1 = Ae^ (Ea1/RT)

    K2 = Ae^ - (Ea2/RT)

    K2 = K1/H

    H = e^ (Ea2/RT - Ea1/RT)

    1.386 = 1/RT (Ea2 - HG Kj/mol)

    Substituting everything to the equation, we get 3.43 kJ/mol
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