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3 September, 16:18

Suppose an assassin uses ricin, a translation inhibitor, to poison her victim. Place the events in chronological order, starting from the poisoning and ending with the death of the victim.

* Ricin is absorbed intot he blood and enters the body's cells.

* Ricin inactivates the 28S rRNA in the large sybunit of the ribosome.

* Ricin binds in the cytoplasm.

* Ribosomes are unable to add new amino acids to polypeptides.

* Multiple organ systems fail

* Protein synthesis halts in many tissues

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  1. 3 September, 16:22
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    Ricin is absorbed intot he blood and enters the body's cells - Ricin binds in the cytoplasm - Ricin inactivates the 28S rRNA in the large sub-unit of the ribosome - then Ribosomes are unable to add new amino acids to polypeptides - then Protein synthesis halts in many tissues - and finally Multiple organ systems fail.

    Explanation:

    1. First of all, Ricin is absorbed into the blood and enters the body's cells. The ricin needs to enter your body's cells, so the ricin first enters your body.

    2. Then it travels through your blood and then it eventually enters a cell s cytoplasm.

    3. Then it interacts with ribosomes and reacts with them on a molecular level (peptide bond catalytic enzyme), which results in that ricin inactivates the 28S rRNA in the large sub-unit of the ribosome.

    4. As a result of the ribosome reacting to ricin, ribosomes are unable to add new amino acids to polypeptides, so protein synthesis within that cell is affected.

    5. Once multiple cells are affected by ricin, then the organ will exhibit its toxic response and finally multiple organ systems fail, and ending with the death of victim.
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