Once a cell enters mitosis, the molecules that activate division must be turned off. what happens to mpf during mitosis? it is completely degraded. it is phosphorylated by a cdk, which inactivates it. the cyclin component of mpf is degraded. the cdk component of mpf is degraded.

I think what happens is that the Cyclin component of the MPF is degraded. MPF or mitosis promoting factor, consists of two important cell cycle regulatory protein called the cyclin and cyclin dependent kinases (CDK). The cdk and the cyclins are the major control switches for the cell cycle, causing the cell to move from G1 to S or G2 to M.