If you were working for a pharmaceutical company as part of a drug discovery team, which of these enzyme inhibitors would you suggest as a productive avenue for drug development?

Option A, a drug to treat high blood pressure that reversibly inhibits an enzyme catalyzing production of a chemical that causes blood vessels to contract

Explanation:

The complete question is

If you were working for a pharmaceutical company as part of a drug discovery team, which of these enzyme inhibitors would you suggest as a productive avenue for drug development?

a) a drug to treat high blood pressure that reversibly inhibits an enzyme catalyzing production of a chemical that causes blood vessels to contract

b) a drug to treat diabetes that irreversibly inhibits an enzyme in the metabolic pathway to synthesize glucose

c) a compound that acts as a competitive inhibitor for a digestive enzyme produced only in the presence of certain foods

d) a compound that inhibits enzymes by significantly changing the ph throughout the body

Solution

Productive avenue of a drug simply means producing an drug that not only treats the main disease or disorder but also functions to inhibit the causative agent activity. In case of option A, both the objectives of producing drug are met and hence it is the right choice.

High blood pressure usually affects the blood vessels by narrowing them and in severe cases may rupture them. If a drug as stated in option A is produced, it will not only rectify the effects of high blood pressure but will also prevent the blood vessels from narrowing by inhibiting the activity of enzymes responsible for producing chemical that leads to blood vessel contraction.

Hence, option A is correct