The most plausible evidence that the development of cancer is a multistep process can be:

A) development of a cancer as a result of activation of a single oncogene by any of a variety of mechanisms

B) usual occurrence of retinoblastoma at a young age

C) fact that proto-oncogenes are widely conserved in evolution

D) observation that certain tumor-suppressor genes and oncogenes are involved in a sequential manner in the development of colon cancer

D) observation that certain tumor-suppressor genes and oncogenes are involved in a sequential manner in the development of colon cancer

Explanation:

Cancer is defined as the abnormal growth of cells of the body. These cells multiply/replicate without control thereby forming a lump or tumor.

Cancer growth has 5 stages and they go though different multi level steps. Different finding backs this up and it includes observation about certain tumor-suppressor genes and oncogenes being involved in a sequential manner in the development of colon cancer.

option d: observation that certain tumor-suppressor genes and oncogenes are involved in a sequential manner in the development of colon cancer

Explanation:

Cancer is known to be a form of genetic disease/ailment that occurs as a result of mutation (one to many). the mutations embedded in the cell undergoes several cellular multiplication which therefor lead to the large growth of the size of tumor, malignant and disorganization.

The development of cancer undergoes a multi-step process. due to the fact that the cells of the human / animal is abnormal in in it cancerous growth, they gain new potentials and capabilities. The cells undergoes division thereby affecting the closeby normal cells. some cancers do have similar characteristics while other cancers most times has different steps,