What neurotransmitter systems do methylated amphetamines affect?

Methamphetamine is neurotoxic to dopaminergic neurons in the human’s midbrain. It increases the amount of the dopamine in the brain and as a result, produces the euphoria feeling that many people experience. It is also indicated that high-dose methamphetamine use can be neurotoxic to serotonin neurons (with the potential of damaging neurons).