Alzheimer's disease is characterized by:

a. TDP-43 and APOE-4

b. hydrocephaly, shuffling gait, and soft voice

c. White matter hyperintensities caused by multiple infarcts

d. Amyloid Plaques and Tau Neurofibrillary Tangles

The correct answer is d amyloid plaques and Tau neurofibrillary tangles.

Explanation:

Alzheimer"s disease is one of the most devastating neurodegenerative disease occur in human.

Alzheimer disease is caused due to the accumulation of amyloid precursor protein or misfolded proteins in the brain resulting in the formation of neurofibrillary tangles which ultimately leads to degeneration and loss of most of the vital functions of neurons.