What are the conditions that lead to a "beer gut" due to the excess consumption of alcohol? NADH produced from the metabolism of ethanol stimulates the citric acid cycle for glucose-derived acetyl CoA. Excess ethanol metabolism leads to an accumulation of NADH that inhibits fatty acid metabolism. The processing of acetate in the liver becomes inefficient leading to a pH imbalance in liver cells, reducing enzyme efficiency in general. NADH inhibits ketone body formation, stimulating glucose rather than fatty acid metabolism. NADH stimulates citric acid cycle enzymes that stimulates glucose-derived acetyl CoA metabolism.
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