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12 June, 06:12

Ln mammalian cells, the synthesis of fatty acids is catalyzed by a multifunctional protein named: a) Acetyl CoA Carboxylase

b) Carnitine acyltransferase

c) Fatty acid synthase

d) B-ketoacyl synthetase

e) Acyl carrier protein

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  1. 12 June, 06:31
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    c) Fatty acid synthase

    Explanation:

    Fatty acid synthase is an enzyme complex with multiple domains with various enzymatic activities such as condensation, reduction, dehydration, etc.

    For example, the enzyme has condensation (KS) activity it domain 1 which in turn catalyze the condensation of activated acetyl and malonyl group to form acetoacetyl-ACP.

    Reduction of acetoacetyl ACP into D-beta-hydroxybutyryl-ACP is catalyzed by beta - ketoacyl-ACP reductase (KR) activity of fatty acid synthase.

    Likewise, the enzyme complex also functions as dehydratase (DH) and reductase (ER) to catalyze the dehydration of beta-hydroxybutyryl-ACP and reduction of double bond respectively.
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