A child who is being evaluated for an immune deficiency fails to make antibody to tetanus toxoid or pneumococcal vaccine, but shows normal cell-mediated immunity as indicated by a positive skin test (swelling and redness) to a commonly encountered environmental antigen. this child has an abnormality of which cell lineage? think in: cellular immunity vs humoral immunity

Question

Giovani Riggs

Biology

3 July, 00:41

A child who is being evaluated for an immune deficiency fails to make antibody to tetanus toxoid or pneumococcal vaccine, but shows normal cell-mediated immunity as indicated by a positive skin test (swelling and redness) to a commonly encountered environmental antigen. this child has an abnormality of which cell lineage? think in: cellular immunity vs humoral immunity

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Nevaeh Williams · Answer 1

The answer is B cell lineage. There two stages of B cells Lineage first is the early pro b cell - D and J rearrangement and the late Pro B cell - V-DJ rearrangement. These rearrangements refer to the Heavy chain and activation of KIT causes the B-cell to proliferate.