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13 October, 08:21

Which of the following sequences is correct? A. binding of a signaling molecule to its receptor → G protein activation → phospholipase C activation → IP3 production → increase in cytoplasmic calcium concentrationB. binding of a growth factor to its receptor → phosphorylation cascade → activation of transcription factor → transcriptionC. binding of a signaling molecule to its receptor → G protein activation → adenylyl cyclase activation → cAMP production → protein phosphorylationD. diffusion of a signaling molecule across the plasma membrane → binding of the signaling molecule to its receptor → movement of the signaling molecule-receptor complex into the nucleus → transcriptionE. All of the choices are correct.

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  1. 13 October, 08:50
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    Answer: All of the choices are correct

    Explanation: Signal transduction converts extracellular signals into intracellular signals and a signaling molecule (ligand / first messenger) reaches its target cell and binds to a specific receptor, this in turn activates a signaling cascade involving intracellular enzymes and molecules (second messengers), which leads to a specific reaction. Through signal amplification, the number of signaling molecules is increased at every step of the signal cascade.

    The receptor is a protein that receives signals, binds the ligand and then initiates an intracellular sequence. It is subdivided into Intracellular, cell surface and nuclear receptor

    Ligand / First Messenger is a chemical messenger that binds to 1 receptor

    The second messenger are small molecules and they transfer the intracellular response to an extracellular stimulus e. g cGMP
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