What is a true difference between prokaryotic and eukaryotic sells

The true difference between the two cells is prokaryotes

a microscopic single-celled organism that has neither a distinct nucleus with a membrane nor other specialized organelles. On the other hand, Eukaryotes are organisms consisting of a cell or cells in which the genetic material is DNA in the form of chromosomes contained within a distinct nucleus. Eukaryotes include all living organisms other than the eubacteria and archaebacteria.