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22 June, 15:04

The A159E mutation causes an A amino acid to be replaced with an E amino acid (their structures are shown here). What effects do you think the A159E mutation will have on the troponin protein?

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  1. 22 June, 15:13
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    Due to hydrophilic nature of E amino acid, it will make it self to be exposed on protein surface and will disrupt the structure and potentially the function of troponin.

    Explanation:

    Since the E amino acid is hydrophilic, it will try to be exposed on the surface of the protein and thus will disrupt the tertiary structure and potentially the function of troponin.
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