A splinter penetrated into the skin of the sole of the foot, almost to the papillary region of the dermis. which layer of the epidermis would be the final layer injured? granulosum basale lucidum spinosum

The answer is stratum basale

Epidermis is made of 5 layer of skin. The deepest layer of epidermis is called stratum basale. The cell in this layer will keep dividing and move to the upper layer. Since the cell is dividing, you will find nucleus inside the cell of this layer. Upper layer of skin slowly become keratinized and lose their organelle.