The renin-angiotensin-aldosterone system is a negative feedback system that plays a central role in blood pressure regulation. How does the end result of this feedback loop regulate blood pressure in the body?

The renin-angiotensin-aldosterone system (RAAS) is a signaling pathway responsible for regulating the body's blood pressure.

The renin-angiotensin-aldosterone system of the kidneys regulates blood volume.

-In response to rising blood pressure, the juxtaglomerular cells in the kidneys secrete renin into the blood. Renin converts the plasma protein angiotensinogen to angiotensin I, which in turn is converted to angiotensin II by enzymes from the lungs.

-Angiotensin II activates two mechanisms that raise blood pressure:

1. Angiotensin II constricts blood vessels throughout the body (raising blood pressure by increasing resistance to blood flow). Constricted blood vessels reduce the amount of blood delivered to the kidneys, which decreases the kidneys' potential to excrete water (raising blood pressure by increasing blood volume).

2. Angiotensin II stimulates the adrenal cortex to secrete aldosterone, a hormone that reduces urine output by increasing retention of H 2O and Na + by the kidneys (raising blood pressure by increasing blood volume).