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12 July, 16:00

Acetyl-CoA can be generated by which three metabolic pathways for potential use by the Citric Acid Cycle for energy metabolism?

a) Glycolysis, Gluconeogenesis, Fatty acid oxidation

b) Gluconeogenesis, amino acid degradation, fatty acid oxidation

c) Glycolysis, amino acid degradation, fatty acid oxidation

d) Glycolysis, amino acid synthesis, fatty acid oxidation

e) Glycolysis, cholesterol degradation, fatty acid oxidation

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Answers (1)
  1. 12 July, 16:16
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    C is the correct option.

    Explanation:

    Glycolysis is the standard way for the formation of acetyl-CoA, from glucose.

    Second, beta-oxidation of fatty acids generates 2 acetyl-coA molecules per cycle.

    Finally, the degradation of amino acids generates intermediates of the Krebbs cycle. Occasionally Leucine, tryptophan and isoleucine are directly catalysed in acetyl-CoA.
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