An NP student did a medication reconciliation while taking a history. The patient has been taking sucralfate [Carafate] and Amoxicillin to treat peptic ulcer disease. The student asks the NP about the pharmacokinetics of sucralfate. Which statement by the student indicates a need for further teaching?

a."Sucralfate adheres to the ulcer and blocks the back-diffusion of hydrogen ions."

b."Sucralfate and ciprofloxacin should be administered 1 hour apart."

c."Sucralfate does not cause systemic side effects."

d."Sucralfate has a moderate acid-neutralizing capacity.

Answer:

D.

Explanation:

Peptic Ulcer is caused by activities of Helicobacter pyroli, and wearing (erosion) of the gastric mucosa of the G. I. This causes inflammation of the localized part of the stomach. This results in pain from the sores produced

. Anagelsics, is given reduce pain, antibiotics to kill the bacteria, and medication to neutralized elevated acids and suppress it are usually administered.

Therefore, any drug that will not neutralize the elevated acid effects of the stomach HCL acid should not be administered.

Sucaralfate lacks acidic neutralizing capacity, needed to suppress the acidity of the G. I by blocking efflux of H + ions., therefore it is the Odd option in the group.