Cancer can result from disruptions in cell cycle control. Mutations that increase the production of EGFR have been associated with skin cancer of the head and neck. Describe how a mutation outside of the coding region of a gene that encodes EGFR could lead to the overproduction of EGFR protein in a skin cell.

Question

Royce

Biology

9 November, 10:40

Cancer can result from disruptions in cell cycle control. Mutations that increase the production of EGFR have been associated with skin cancer of the head and neck. Describe how a mutation outside of the coding region of a gene that encodes EGFR could lead to the overproduction of EGFR protein in a skin cell.

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Paulina Burke · Answer 1

-Mutation in regulatory sequence (promoter or enhancer) could increase rate of transcription of EGFR gene.

-Mutation in transcription factor could increase production of mRNA, which would lead to production of more polypeptide

-Gene duplication may increase production of EGFR

-Gene translocation may inactivate repressor

-Mutation in repressor gene may remove controls on cell division

-Change in mRNA sequence may increase translation efficiency or mRNA stability

Elias Pennington · Answer 2

The rate of transcription can be increased by a mutation of EGFR gene and resulting in the overproduction of EFGR (polpeptide) and a skin cell.

Mutation alongwith transcription factor could enhance the synthesis of mRNA, which ultimately leads to production of more polypeptide.

Gene duplication could enhance synthesis of EGFR.